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gyy4137  (MedChemExpress)


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    MedChemExpress gyy4137
    Gyy4137, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gyy4137/product/MedChemExpress
    Average 94 stars, based on 10 article reviews
    gyy4137 - by Bioz Stars, 2026-02
    94/100 stars

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    H 2 S could inhibit ferritinophagy and ferroptosis activated by SCIRI. (a) Schematic diagram depicts the operation and different treatments for rats. (b) Relative concentrations of GSH, MDA, and Fe 2+ of the spinal cord in the Sham, SCIRI, SCIRI <t>+</t> <t>GYY4137,</t> SCIRI + GYY4137 + <t>Erastin,</t> and SCIRI + GYY4137 + Rapa group ( n = 6 rats per group). (c) The NeuN and DHE immunofluorescence colocalization staining of the spinal cord in each group, red (DHE), green (NeuN) and blue (DAPI) (200×, scale bar = 100 μm, n = 3 rats per group). (d) The GPx4 and TFRC immunohistochemistry staining of the spinal cord in each group (200×, scale bar = 100 μm, n = 3 rats per group). (e) Western blotting was used to detect the protein expression of NCOA4 and ferritin of the spinal cord in each group. (f) Densitometric analysis and quantification of Ncoa4/Actin and ferritin/Actin ( n = 6 rats per group). (g) The LC3 and ferritin immunofluorescence colocalization staining of the spinal cord in each group, red (ferritin), green (LC3) and blue (DAPI) (200×, scale bar = 100 μm, n = 3 rats per group). ** p < 0.01; *** p < 0.01; n.s., not significant.
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    H 2 S could inhibit ferritinophagy and ferroptosis activated by SCIRI. (a) Schematic diagram depicts the operation and different treatments for rats. (b) Relative concentrations of GSH, MDA, and Fe 2+ of the spinal cord in the Sham, SCIRI, SCIRI + GYY4137, SCIRI + GYY4137 + Erastin, and SCIRI + GYY4137 + Rapa group ( n = 6 rats per group). (c) The NeuN and DHE immunofluorescence colocalization staining of the spinal cord in each group, red (DHE), green (NeuN) and blue (DAPI) (200×, scale bar = 100 μm, n = 3 rats per group). (d) The GPx4 and TFRC immunohistochemistry staining of the spinal cord in each group (200×, scale bar = 100 μm, n = 3 rats per group). (e) Western blotting was used to detect the protein expression of NCOA4 and ferritin of the spinal cord in each group. (f) Densitometric analysis and quantification of Ncoa4/Actin and ferritin/Actin ( n = 6 rats per group). (g) The LC3 and ferritin immunofluorescence colocalization staining of the spinal cord in each group, red (ferritin), green (LC3) and blue (DAPI) (200×, scale bar = 100 μm, n = 3 rats per group). ** p < 0.01; *** p < 0.01; n.s., not significant.

    Journal: CNS Neuroscience & Therapeutics

    Article Title: Hydrogen Sulfide Sustained Release Donor Alleviates Spinal Cord Ischemia–Reperfusion‐Induced Neuron Death by Inhibiting Ferritinophagy‐Mediated Ferroptosis

    doi: 10.1111/cns.70366

    Figure Lengend Snippet: H 2 S could inhibit ferritinophagy and ferroptosis activated by SCIRI. (a) Schematic diagram depicts the operation and different treatments for rats. (b) Relative concentrations of GSH, MDA, and Fe 2+ of the spinal cord in the Sham, SCIRI, SCIRI + GYY4137, SCIRI + GYY4137 + Erastin, and SCIRI + GYY4137 + Rapa group ( n = 6 rats per group). (c) The NeuN and DHE immunofluorescence colocalization staining of the spinal cord in each group, red (DHE), green (NeuN) and blue (DAPI) (200×, scale bar = 100 μm, n = 3 rats per group). (d) The GPx4 and TFRC immunohistochemistry staining of the spinal cord in each group (200×, scale bar = 100 μm, n = 3 rats per group). (e) Western blotting was used to detect the protein expression of NCOA4 and ferritin of the spinal cord in each group. (f) Densitometric analysis and quantification of Ncoa4/Actin and ferritin/Actin ( n = 6 rats per group). (g) The LC3 and ferritin immunofluorescence colocalization staining of the spinal cord in each group, red (ferritin), green (LC3) and blue (DAPI) (200×, scale bar = 100 μm, n = 3 rats per group). ** p < 0.01; *** p < 0.01; n.s., not significant.

    Article Snippet: GYY4137 (HY‐107632), rapamycin (AY‐22989), and erastin (HY‐15763) were purchased from MedChemExpress.

    Techniques: Immunofluorescence, Staining, Immunohistochemistry, Western Blot, Expressing